1-Naphthyl PP1(1-NA-PP1)

Catalog No.S2642 Batch:S264201

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Technical Data

Formula

C19H19N5

Molecular Weight 317.39 CAS No. 221243-82-9
Solubility (25°C)* In vitro DMSO 9 mg/mL (28.35 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description 1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.
Targets
PKD3 [1]
(Cell-free assay)
PKD2 [1]
(Cell-free assay)
PKD1 [1]
(Cell-free assay)
v-Fyn [2]
(Cell-free assay)
c-Abl [2]
(Cell-free assay)
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109.4 nM 133.4 nM 154.6 nM 0.6 μM 0.6 μM

Protocol (from reference)

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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