Effect of hyperthermia alone and in combination with anticancer drugs on the viability of P388 leukemic cells

Effect of local tumor hyperthermia (42 degrees C) at various intervals ranging from 1 to 5 h and in combination with antineoplastic drugs was investigated on P388 murine lymphocytic leukemic cells by using an in vitro-in vivo bioassay method. It was observed that a 1-h exposure resulted in a one log cell kill. In combination studies with hyperthermia and anticancer drugs, 1-h exposure to hyperthermia along with 10 micrograms/ml in vitro concentration of adriamycin (NSC 23127), vincristine (NSC 67574), or 5-fluorouracil (NSC 19893) resulted in the synergistic cell killing action against P388 leukemic cells. However, cyclophosphamide (NSC 26271) and cytosine arabinoside (NSC 63878) did not show any enhanced therapeutic effect.

 

Comments：

An investigation into the effects of local tumor hyperthermia at 42°C combined with antineoplastic drugs found that a 1-hour exposure resulted in a one-log cell kill, with a synergistic cell killing effect against P388 leukemic cells when combined with adriamycin, vincristine, or 5-fluorouracil, but no enhanced effect with cyclophosphamide or cytosine arabinoside.

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