Nicotinamide Riboside Chloride

Catalog No.S2935 Batch:S293501

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Technical Data

Formula

C11H15ClN2O5

Molecular Weight 290.7 CAS No. 23111-00-4
Solubility (25°C)* In vitro DMSO 58 mg/mL (199.51 mM)
Water 58 mg/mL (199.51 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
In vitro

Nicotinamide Riboside supplementation increases NAD+ content and sirtuin activity in cultured mammalian cells.[1]

In vivo

Nicotinamide Riboside, a precursor to nicotinamide adenine dinucleotide(NAD), restores tissue NAD+ depletion induced by acute kidney injury (AKI) to that of the sham group, increases autophagy and sirtuin1 (Sirt1).[2]

Protocol (from reference)

Cell Assay:

[1]

  • Cell lines

    C2C12 myotubes, Hepa1.6 and HEK293T cells

  • Concentrations

    0-1000 μM

  • Incubation Time

    24 h

  • Method

    --

Animal Study:

[2]

  • Animal Models

    Two-month-old male Wistar rats

  • Dosages

    500 g/kg/day

  • Administration

    o.g.

Selleck's Nicotinamide Riboside Chloride has been cited by 6 publications

Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation [ Front Physiol, 2023, 14:1164287] PubMed: 37650111
DEVELOPMENT OF MURINE BRAIN ORGANOIDS AND THEIR APPLICATON FOR DISEASE MODELING [ IRIS, 2023, ] PubMed: none
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming [ Cell Discov, 2022, 8(1):106] PubMed: 36220812
Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation [ Cell Death Differ, 2022, 10.1038/s41418-022-00992-3] PubMed: 35568718
Aberrant NAD+ metabolism underlies Zika virus-induced microcephaly [ Nat Metab, 2021, 3(8):1109-1124] PubMed: 34385701
Effect of NAD+ boosting on kidney ischemia-reperfusion injury [ PLoS One, 2021, 16(6):e0252554] PubMed: 34061900

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.