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Taurolidine

Synonyms: Taurolin, Tauroline, Tauroflex

Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.

Taurolidine Chemical Structure

Taurolidine Chemical Structure

CAS No. 19388-87-5

Purity & Quality Control

Batch: S488501 DMSO]56 mg/mL]false]]]false]]]false Purity: 98%
98

Taurolidine Related Products

Biological Activity

Description Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.
In vitro
In vitro Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro[1]. Taurolidine possesses antineoplastic activity. The antiproliferative IC50 of taurolidine is in the 10-50 μM range, approximately 100-fold lower that that required for its antibiotic effects. Exposure to taurolidine induces apoptosis in SKOV-3 and PA-1 human tumor cells but apparently not in NIH-3T3 fibroblasts[2]. Taurolidine causes significant in vitro growth inhibition and cytotoxicity of human MM cells, which appears to be due, at least in part, to apoptosis[3].
Cell Research Cell lines a rat metastatic colorectal tumor cell line (DHD/K12/TRb)
Concentrations 5, 10, 15, 25 mg/ml
Incubation Time 14 h
Method DHD/K12/TRb cells (1×105 cells/ml) are cultured in 24-well plates and incubated for 6 hours at 37°C in humidified 5% CO2 conditions to allow the cells to adhere. Culture medium is then removed and fresh culture medium alone (control) or culture medium with 5, 10, 15, and 25 mg/ml of Taurolidine is added. Cells are then incubated at 37°C in humidified 5% CO2 conditions for a further 14 hours followed by addition of 10 ml of BrdU labeling solution.
In Vivo
In vivo In BD IX rats that underwent laparotomy, intraperitoneal instillation of DHD/K12/TRb tumor cells, local/intraperitoneal administration of taurolidine results in a marked decrease in tumor burden compared with control animals[1]. The i.p. administration of taurolidine effectively inhibits the development and growth of ovarian tumors when therapy is initiated on the day of tumor cell injection[2]. i.p. taurolidine inhibits adherence of colon tumor cells injected into the peritoneal cavity of rats[3].
Animal Research Animal Models Adult male syngenic BD IX rats, aged 8-10 weeks
Dosages 100 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02279121 Completed
Catheter-Related Infections
Centre Hospitalier Régional Metz-Thionville|centre régional de pharmacovigilance de Nancy|Theradial
 November 2014 Not Applicable

Chemical Information & Solubility

Molecular Weight 284.36 Formula

C7H16N4O4S2
CAS No. 19388-87-5 SDF --
Smiles C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (196.93 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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