Home Microbiology Bacterial chemical Silver Sulfadiazine For research use only.

Silver Sulfadiazine

Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.

Silver Sulfadiazine Chemical Structure

Silver Sulfadiazine Chemical Structure

CAS No. 22199-08-2

Purity & Quality Control

Batch: S482201 4-Methylpyridine]3 mg/mL]true]DMSO]0.1 mg/mL]false]Water]Insoluble]false Purity: 98%
98

Silver Sulfadiazine Related Products

Biological Activity

Description Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.
In vitro
In vitro The inhibitory effect of Ag-SD on keratinocyte and fibroblast growth induced the retardation of wound closure rate[1].
Cell Research Cell lines HaCaT cells
Concentrations 0.5%-1%
Incubation Time 1 week
Method

Human HaCaT keratinocytes were incubated in 2-ml Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum. The cultures were maintained up to 80% confluence in 35-mm petridish before treating with Ag-SD and EGF. Samples of collagen sponge disk (0.2 cm2) were prepared by soaking in different concentrations of Ag-SD and/or EGF solutions and freeze-dried. Before usage, the sponges were sterilized by g-irradiation. The sterile sponges of 30-mm diameter were placed in 6-well tissue culture plate, seeded with 0.8×105 HaCaT cells per sponge and cultured in 5% CO2 and 95% humidity for 1 week. Cell viability was assessed by the MTT method.
In Vivo
In vivo Silver sulfadiazine is considered the gold standard for burn treatment[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00413738 Completed
Infection
Centre National de Greffe de Moelle Osseuse
 December 2006 Phase 3

Chemical Information & Solubility

Molecular Weight 357.14 Formula

C10H9AgN4O2S
CAS No. 22199-08-2 SDF --
Smiles C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
Storage (From the date of receipt)

In vitro
Batch:

4-Methylpyridine : 3 mg/mL

DMSO : 0.1 mg/mL ( (0.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Silver Sulfadiazine | Silver Sulfadiazine ic50 | Silver Sulfadiazine price | Silver Sulfadiazine cost | Silver Sulfadiazine solubility dmso | Silver Sulfadiazine purchase | Silver Sulfadiazine manufacturer | Silver Sulfadiazine research buy | Silver Sulfadiazine order | Silver Sulfadiazine mouse | Silver Sulfadiazine chemical structure | Silver Sulfadiazine mw | Silver Sulfadiazine molecular weight | Silver Sulfadiazine datasheet | Silver Sulfadiazine supplier | Silver Sulfadiazine in vitro | Silver Sulfadiazine cell line | Silver Sulfadiazine concentration | Silver Sulfadiazine nmr