Home Apoptosis Other chemical S-allyl-L-cysteine For research use only.

S-allyl-L-cysteine

Synonyms: S-Allylcysteine

S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.

S-allyl-L-cysteine Chemical Structure

S-allyl-L-cysteine Chemical Structure

CAS No. 21593-77-1

Purity & Quality Control

S-allyl-L-cysteine Related Products

Biological Activity

Description S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.
In vitro
In vitro S-Allyl cysteine (SAC) could suppress NF-κB activation and lower nitric oxide (NO) production in interferon-γ-stimulated RAW264.7 cells[2]. SAC is known for its anti-apoptotic and antioxidant effects in a range of types of somatic cells. SAC manifests antioxidant properties for example in the nervous and cardiovascular systems[3].
Cell Research Cell lines Oocytes
Concentrations 0.1, 0.5, 1.0 and 5.0 mM
Incubation Time 24 and 48 h
Method --
In Vivo
In vivo SAC significantly prevents NSAID-induced gastric ulceration by blocking inflammation[1]. The dietary intake of SAC suppresses protein expression of NF-κB, MAPK, and PKC in kidney of diabetic mice, which in turn declines renal activity and mRNA expression of NOS and COX-2, finally lowers the formation of ROS, nitric oxide, IL-6, TNF-α, and PGE2, as well as improves renal functions. Therefore, SAC is potent anti-inflammatory agents against diabetic nephropathy[2].
Animal Research Animal Models male C57BL/6 mice
Dosages 3, 10, 30 mg/kg
Administration by gavage

Chemical Information & Solubility

Molecular Weight 161.22 Formula

C6H11NO2S
CAS No. 21593-77-1 SDF Download S-allyl-L-cysteine SDF
Smiles C=CCSCC(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 32 mg/mL

DMSO : 4 mg/mL ( (24.81 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy S-allyl-L-cysteine | S-allyl-L-cysteine supplier | purchase S-allyl-L-cysteine | S-allyl-L-cysteine cost | S-allyl-L-cysteine manufacturer | order S-allyl-L-cysteine | S-allyl-L-cysteine distributor