Home Neuronal Signaling Dopamine Receptor agonist Rotigotine For research use only.

Rotigotine

Synonyms: N-0923

Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

Rotigotine Chemical Structure

Rotigotine Chemical Structure

CAS No. 99755-59-6

Purity & Quality Control

Batch: S427401 DMSO]63 mg/mL]false]Ethanol]63 mg/mL]false]Water]Insoluble]false Purity: 99.97%
99.97

Rotigotine Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

Biological Activity

Description Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.
Targets
Dopamine receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02728947 Completed
Parkinson''s Disease
Luye Pharma Group Ltd.
 May 2016 Phase 1
NCT02070796 Completed
Healthy
UCB Pharma SA|UCB Pharma
 February 2014 Phase 1
NCT01675024 Completed
Healthy
UCB Pharma
 August 2012 Phase 1
NCT02786667 Unknown status
Parkinson Disease|Apathy
University Hospital Grenoble
 June 2012 Phase 3
NCT01565018 Completed
Healthy Volunteers
UCB Pharma|Otsuka Pharmaceutical Co. Ltd.
 March 2012 Phase 1

Chemical Information & Solubility

Molecular Weight 315.47 Formula

C19H25NOS
CAS No. 99755-59-6 SDF Download Rotigotine SDF
Smiles CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 63 mg/mL ( (199.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 63 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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