Home Metabolism PPAR agonist Rosiglitazone HCl For research use only.

Rosiglitazone HCl

Synonyms: BRL-49653 HCl

Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Rosiglitazone HCl Chemical Structure

Rosiglitazone HCl Chemical Structure

CAS No. 302543-62-0

Purity & Quality Control

Rosiglitazone HCl Related Products

Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

Biological Activity

Description Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
Targets
PPAR [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02737709 Terminated
Non-small Cell Lung Cancer
Sun Yat-sen University
 March 2016 Phase 2
NCT01402076 Completed
Healthy Volunteers
Vanda Pharmaceuticals
 August 2011 Phase 1
NCT01415128 Completed
Erectile Dysfunction
VIVUS LLC
 April 2010 Phase 1
NCT01100619 Completed
Papillary Thyroid Cancer|Follicular Thyroid Cancer|Huerthle Cell Thyroid Cancer|Renal Cell Carcinoma
Exelixis
 April 2010 Phase 1
NCT01376063 Completed
Healthy Adult Subjects
FibroGen
 March 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 393.89 Formula

C18H19N3O3S.HCl
CAS No. 302543-62-0 SDF Download Rosiglitazone HCl SDF
Smiles CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (200.56 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 79 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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