Pramoxine HCl

Name: Pramoxine HCl
Brand: Selleck Chemicals
SKU: S4092
Rating: 5 (1 reviews)

Synonyms: Pramocaine hydrochloride

Catalog No.S4092 Purity:99.89%

Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties.

Pramoxine HCl Chemical Structure

CAS No. 637-58-1

Purity & Quality Control

Batch: S409201 DMSO]66 mg/mL]false]Water]66 mg/mL]false]Ethanol]66 mg/mL]false Purity: 99.89%

99.89

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Biological Activity

Description	Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties.

In vitro
In vitro	Pramoxine is used primarily in combination with colloidal oatmeal, hydrocortisone, menthol, and petrolatum. ^[1]

In Vivo
In vivo	Pramoxine (1.7 mM) causes a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine and barium chloride on the guinea-pig ileum. Pramoxine exhibits anesthetic inhibitory potency on the guinea-pig ileum with pKa of 6.4. ^[2] Pramoxine produces shifts in specific skin temperature at which activation and suppression of both panting and shivering occur in dogs, these changes are interpreted as indicating peripheral mediation in control of thermoregulatory end mechanisms. ^[3]

References

Chemical Information & Solubility

Molecular Weight	329.86	Formula	C₁₇H₂₇NO₃.HCl
CAS No.	637-58-1	SDF	Download Pramoxine HCl SDF
Smiles	CCCCOC1=CC=C(C=C1)OCCCN2CCOCC2.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 66 mg/mL ( (200.08 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 66 mg/mL

Ethanol : 66 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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