Home Neuronal Signaling GABA Receptor agonist Phenibut For research use only.

Phenibut

Synonyms: Aminophenylbutyric acid, Fenibut, Fenigam, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA

Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.

Phenibut Chemical Structure

Phenibut Chemical Structure

CAS No. 1078-21-3

Purity & Quality Control

Phenibut Related Products

Signaling Pathway

GABA Receptor Signaling Pathways

GABA Receptor Signaling Pathway

Biological Activity

Description Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.
Targets
GABA receptor [1]
In vitro
In vitro

Phenibut has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABAB and, to some extent, at GABAA receptors. It also stimulates dopamine receptors and antagonizes β-phenethylamine (PEA), a putative endogenous anxiogenic[1].
In Vivo
In vivo

At doses that do not affect motor activity (e.g., 20 mg/kg i.p.), Phenibut inhibits food conditioned reflexes in mice. At doses higher than 70 mg/kg i.p., Phenibut reduces motor and exploratory activities, rearings, muscle tone, coordination and body temperature. Following intravenous administration to either rabbits or rats phenibut is not metabolized. Phenibut is largely excreted in the urine. At 15, 30, 60, or 90 min following i.v. administration Phenibut is found in liver, kidneys, and urine. Traces of phenibut are found in blood and brain. 180 min after i.v. injection only traces of the drug are found in all tissues studied. In cats and dogs, phenibut, after a single dose of 50 mg/kg i.v., is excreted in the urine unchanged. The acute toxicity of phenibut is low. Its LD50 is 900 mg/kg i.p. in mice and 700 mg/kg i.p. in rats[1]. Phenibut administration leads to decreases in horizontal movement activity and some elements of investigative behavior in rabbits in the open field, along with decreases in the reactivity of the animals to emotionally significant stimuli[2].
Animal Research Animal Models Chinchilla rabbits
Dosages 40 mg/kg
Administration s.c.

Chemical Information & Solubility

Molecular Weight 179.22 Formula

C10H13NO2
CAS No. 1078-21-3 SDF --
Smiles C1=CC=C(C=C1)C(CC(=O)O)CN
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 36 mg/mL ( (200.87 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 36 mg/mL

Ethanol : 36 mg/mL


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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