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Paromomycin Sulfate

Synonyms: Aminosidine sulfate

Paromomycin Sulfate(Aminosidine sulfate) is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.

Paromomycin Sulfate Chemical Structure

Paromomycin Sulfate Chemical Structure

CAS No. 1263-89-4

Purity & Quality Control

Paromomycin Sulfate Related Products

Biological Activity

Description Paromomycin Sulfate(Aminosidine sulfate) is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.
Targets
16S ribosomal RNA [1]
In vitro
In vitro

Paromomycin is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. [1] In vitro analysis on the sensitivity of amastigotes in a murine macrophage model showed that L. major and L. tropica isolates (ED50s in the range of 1 to 5 μM) are more sensitive than L. braziliensis (ED50, <12 μM) and L. mexicana (ED50, 39 μM) isolates. L. donovani shows intermediate sensitivity (ED50, 6 to 18 μM), except for one Indian strain, DD8, which had an ED50 of >150 μM. [2]
In Vivo
In vivo

In both experimental models and clinical cases of CL, lesions caused by L. major treated with paromomycin ointment resolved faster and more completely than lesions caused by L. amazonensis and L. panamensis. [2]

Chemical Information & Solubility

Molecular Weight 713.71 Formula

C23H45N5O14.xH2SO4
CAS No. 1263-89-4 SDF Download Paromomycin Sulfate SDF
Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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