Home Protein Tyrosine Kinase VEGFR inhibitor - FGFR inhibitor - PDGFR inhibitor Nintedanib Ethanesulfonate Salt For research use only.

Nintedanib Ethanesulfonate Salt

Synonyms: Intedanib, BIBF 1120

Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.

Nintedanib Ethanesulfonate Salt Chemical Structure

Nintedanib Ethanesulfonate Salt Chemical Structure

CAS No. 656247-18-6

Purity & Quality Control

Nintedanib Ethanesulfonate Salt Related Products

Signaling Pathway

VEGFR Signaling Pathways

VEGFR Signaling Pathway

Biological Activity

Description Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.
Targets
VEGFR2 [1]
(Cell-free assay)		 VEGFR3 [1]
(Cell-free assay)		 VEGFR1 [1]
(Cell-free assay)		 FGFR2 [1]
(Cell-free assay)		 PDGFRα [1]
(Cell-free assay)		 Click to View More Targets
13 nM 13 nM 34 nM 37 nM 59 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06200714 Recruiting
Idiopathic Pulmonary Fibrosis|Diarrhoea
Boehringer Ingelheim
 April 30 2024 --
NCT05676112 Withdrawn
Pulmonary Fibrosis
Boehringer Ingelheim|China-Japan Friendship Hospital
 December 29 2023 --
NCT06070610 Completed
Healthy
Boehringer Ingelheim
 November 8 2023 Phase 1
NCT05755308 Not yet recruiting
Idiopathic Pulmonary Fibrosis
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
 October 2023 Not Applicable
NCT06071013 Not yet recruiting
Non-small Cell Lung Cancer|EGFR Gene Mutation|EGFR-TKI Resistant Mutation
China Medical University Hospital
 September 28 2023 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 649.76 Formula

C31H33N5O4.C2H6O3S
CAS No. 656247-18-6 SDF --
Smiles CCS(=O)(=O)O.CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (153.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 10 mg/mL (超声加热10min)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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