Home Angiogenesis Bcr-Abl inhibitor - Autophagy activator - AMPK activator Nilotinib hydrochloride monohydrate For research use only.

Nilotinib hydrochloride monohydrate

Synonyms: Tasigna, AMN-107 hydrochloride monohydrate

Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.

Nilotinib hydrochloride monohydrate Chemical Structure

Nilotinib hydrochloride monohydrate Chemical Structure

CAS No. 923288-90-8

Purity & Quality Control

Batch: S489501 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.98%
99.98

Nilotinib hydrochloride monohydrate Related Products

Signaling Pathway

Bcr-Abl Signaling Pathways

Bcr-Abl Signaling Pathway

Biological Activity

Description Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
Targets
AMPK [1] Bcr-Abl [1]
(in Murine myeloid progenitor cells)
30 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06409936 Not yet recruiting
CML Chronic Phase|Chronic Myeloid Leukemia Chronic Phase|Chronic Myeloid Leukemia BCR/ABL-Positive|Chronic Myeloid Leukemia
Gruppo Italiano Malattie EMatologiche dell''Adulto|Fundacion Espanola para la Curacion de la Leucemia Mieloide Cronica
 September 2024 Phase 2
NCT05185947 Recruiting
Gynecologic Cancer|Gynecologic Neoplasms|Peritoneal Carcinomatosis|Peritoneal Neoplasms|Ovarian Cancer|Ovarian Neoplasms|Colorectal Cancer|Colorectal Neoplasms|Appendiceal Cancer|Appendiceal Neoplasms
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 October 13 2022 Phase 2
NCT04326933 Unknown status
Patients Diagnosed as Chronic Meyloid Leukemia
Assiut University
 January 1 2020 --
NCT04002674 Recruiting
Dementia With Lewy Bodies
Georgetown University|National Institutes of Health (NIH)
 July 1 2019 Phase 2

Chemical Information & Solubility

Molecular Weight 583.99 Formula

C28H25ClF3N7O2
CAS No. 923288-90-8 SDF --
Smiles O.Cl.CC1=C[N](C=N1)C2=CC(=CC(=C2)NC(=O)C3=CC(=C(C)C=C3)NC4=NC=CC(=N4)C5=CN=CC=C5)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (171.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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