Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Mupirocin For research use only.

Mupirocin

Synonyms: BRL-4910A,Pseudomonic acid

Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.

Mupirocin Chemical Structure

Mupirocin Chemical Structure

CAS No. 12650-69-0

Purity & Quality Control

Mupirocin Related Products

Signaling Pathway

DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway

Biological Activity

Description Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.
Targets
isoleucyl t-RNA synthetase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06291181 Completed
Staphylococcus Aureus
Sohag University
 January 1 2023 Not Applicable
NCT05251584 Unknown status
Peritoneal Dialysis-related Infection
Phramongkutklao College of Medicine and Hospital|Silpakorn University
 December 1 2021 Not Applicable
NCT03685487 Completed
Staphylococcus Aureus
Centre Hospitalier Universitaire de Saint Etienne
 February 12 2019 --
NCT02967432 Completed
Staphylococcus
Crouse Hospital|Jana Shaw MD|Steven Gross MD|David Martin RN|Dale Franz RPh|Rachel Carey
 October 2016 Phase 2

Chemical Information & Solubility

Molecular Weight 500.62 Formula

C26H44O9
CAS No. 12650-69-0 SDF Download Mupirocin SDF
Smiles CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)O)C)C(C)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (199.75 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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