Home GPCR & G Protein Vasopressin Receptor antagonist Mozavaptan For research use only.

Mozavaptan

Synonyms: OPC-31260

Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.

Mozavaptan Chemical Structure

Mozavaptan Chemical Structure

CAS No. 137975-06-5

Purity & Quality Control

Mozavaptan Related Products

Signaling Pathway

Vasopressin Receptor Signaling Pathways

Vasopressin Receptor Signaling Pathway

Biological Activity

Description Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.
Targets
Vasopressin receptor 2 [2] Vasopressin receptor 1 [2]
14 nM 1.2 μM
In vitro
In vitro Mozavaptan (OPC-31260) is a nonpeptide, orally effective competitive inhibitor of AVP with a V2:V1 receptor selectivity ratio of 25:1 indicating relative V2 receptor selectivity. [1] Mozavaptan (OPC-31260) inhibits AVP binding to V1 and V2 receptors in a competitive manner. [2]
In Vivo
In vivo Mozavaptan (OPC-31260) inhibits the antidiuretic action of exogenously administered AVP in water-loaded, alcohol-anaesthetized rats in a dose-dependent manner. OPC-31260 dose-dependently increases urine flow and decreased urine osmolality after oral administration at doses of 1 to 30 mg/kg in normal conscious rats. [2]
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 10, 30, 100μg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 427.54 Formula

C27H29N3O2
CAS No. 137975-06-5 SDF Download Mozavaptan SDF
Smiles CC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC(C4=CC=CC=C43)N(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 85 mg/mL ( (198.81 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Mozavaptan | Mozavaptan ic50 | Mozavaptan price | Mozavaptan cost | Mozavaptan solubility dmso | Mozavaptan purchase | Mozavaptan manufacturer | Mozavaptan research buy | Mozavaptan order | Mozavaptan mouse | Mozavaptan chemical structure | Mozavaptan mw | Mozavaptan molecular weight | Mozavaptan datasheet | Mozavaptan supplier | Mozavaptan in vitro | Mozavaptan cell line | Mozavaptan concentration | Mozavaptan nmr