Home Microbiology Bacterial chemical Methenamine Hippurate For research use only.

Methenamine Hippurate

Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity.

Methenamine Hippurate Chemical Structure

Methenamine Hippurate Chemical Structure

CAS No. 5714-73-8

Purity & Quality Control

Methenamine Hippurate Related Products

Biological Activity

Description Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04077580 Enrolling by invitation
Recurrent Urinary Tract Infection
University of Oslo|Amsterdam UMC location VUmc|UMC Utrecht|Göteborg University|Medical University of Lodz
 November 1 2019 Phase 4
NCT02358993 Completed
Urinary Tract Infections|Catheter-Related Infections
University of Pennsylvania
 December 2014 Not Applicable

Chemical Information & Solubility

Molecular Weight 319.36 Formula

C15H21N5O3
CAS No. 5714-73-8 SDF --
Smiles C1N2CN3CN1CN(C2)C3.C1=CC=C(C=C1)C(=O)NCC(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 64 mg/mL ( (200.4 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 64 mg/mL

Ethanol : 64 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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