Home Metabolism Carbonic Anhydrase inhibitor Methazolamide For research use only.

Methazolamide

Synonyms: CL 8490

Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

Methazolamide Chemical Structure

Methazolamide Chemical Structure

CAS No. 554-57-4

Purity & Quality Control

Batch: S403901 DMSO]47 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.67%
99.67

Methazolamide Related Products

Signaling Pathway

Carbonic Anhydrase Signaling Pathways

Carbonic Anhydrase Signaling Pathway

Biological Activity

Description Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
Features Methazolamide potently inhibits various isoforms of carbonic anhydrase.
Targets
hCAII [1] bCAIV [1] hCAI [1]
14 nM(Ki) 36 nM(Ki) 50 nM(Ki)
In vitro
In vitro Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. [1] Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles. [2]
In Vivo
In vivo Methazolamide does not impair respiratory work performance in anesthetized rabbits. [2]

Chemical Information & Solubility

Molecular Weight 236.27 Formula

C5H8N4O3S2
CAS No. 554-57-4 SDF Download Methazolamide SDF
Smiles CC(=O)N=C1N(N=C(S1)S(=O)(=O)N)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 47 mg/mL ( (198.92 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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