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Menbutone

Synonyms: Genabilin, Naftobil, Genabilic acid

Menbutone (Genabilin, Naftobil, Genabilic acid), or genabilic acid, is a derivative of oxybutyric acid which acts as a choleretic stimulating secretion, a trypsinogen and a pepsinogen.

Menbutone Chemical Structure

Menbutone Chemical Structure

CAS No. 3562-99-0

Purity & Quality Control

Batch: S488601 DMSO]51 mg/mL]false]]]false]]]false Purity: 99.58%
99.58

Menbutone Related Products

Biological Activity

Description Menbutone (Genabilin, Naftobil, Genabilic acid), or genabilic acid, is a derivative of oxybutyric acid which acts as a choleretic stimulating secretion, a trypsinogen and a pepsinogen.
In Vivo
In vivo Acute toxicity of menbutone in rabbits occurrs at accidental high doses, as the lethal dose is about 50 fold over the recommended therapeutic dose for other animals. Cardiac muscle, liver and kidneys are the main target organs for menbutone toxicity. Menbutone is not recommended for use in rabbits suffering from any cardiac and hepatic disorders, especially in overdosing situations. The calculated LD50 is 475 mg/kg BW in rabbits, indicating that menbutone has a relatively wide safety margin[1].
Animal Research Animal Models healthy adult male rabbits
Dosages 400, 450, 500, 550 and 600 mg/kg
Administration intramuscular injection

Chemical Information & Solubility

Molecular Weight 258.27 Formula

C15H14O4
CAS No. 3562-99-0 SDF --
Smiles COC1=CC=C(C2=CC=CC=C21)C(=O)CCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (197.46 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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