Home Metabolism THR agonist Levothyroxine (L-Thyroxine) sodium For research use only.

Levothyroxine (L-Thyroxine) sodium

Synonyms: L-T4 sodium, LT4 sodium

Levothyroxine (L-Thyroxine) sodium is the major hormone derived from the thyroid gland. It is the agonist of Thyroid hormone receptor alpha and beta.

Levothyroxine (L-Thyroxine) sodium Chemical Structure

Levothyroxine (L-Thyroxine) sodium Chemical Structure

CAS: 55-03-8

Purity & Quality Control

Batch: Purity: 99.56%
99.56

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Biological Activity

Description Levothyroxine (L-Thyroxine) sodium is the major hormone derived from the thyroid gland. It is the agonist of Thyroid hormone receptor alpha and beta.
In vitro
In vitro Levothyroxine can upregulate the expression of P-gp mRNA and protein in LS180 cells and can produce the same effect in Caco-2 cells, which are relatively lacking in PXR. It doea not affect the expression of CYP3A4 in either cell line[1].
Cell Research Cell lines LS180V cells
Concentrations 100 nM and 100 μM
Incubation Time 72 h
Method LS180V cells are induced for 72 h with two different concentrations of l-T4: 100 nM and 100 μM.
In Vivo
In vivo Levothyroxine is a synthetic T4 hormone that is biochemically and physiologically indistinguishable from the natural one, and it is administered when the body is deficient in the natural hormone. Its nain site of absorption is small intestine, more specifically through the duodenum, jejunum and ileum. Very little is absorbed in the stomach. The bioavailability is about 70-80 % in euthyroid person and may be slightly higher in hyperthyroid patients. The absorption of levothyroxine appears to be influenced by gastric pH. Tmax=2-3 hours and the half-time T1/2 is 6.2 and 7.5 days in euthyroid and hypothyroid patients, respectively[3]. T4 hormones is known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. T4-treatment induces a dose-dependent increase in the duration of contractions. Abnormal uterine contractile pattern are induced by T4-treatment[2].
Animal Research Animal Models Sprague-Dawley rats
Dosages 20 μg/kg/day and 100 μg/kg/day
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04037748 Completed
Healthy
Merck Healthcare KGaA Darmstadt Germany an affiliate of Merck KGaA Darmstadt Germany
 June 25 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 798.85 Formula

C15H10I4NO4.Na
CAS No. 55-03-8 SDF Download Levothyroxine (L-Thyroxine) sodium SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (125.17 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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