Home Transmembrane Transporters CFTR chemical Icenticaftor (QBW251) For research use only.

Icenticaftor (QBW251)

Synonyms: NVP-QBW251

Icenticaftor (QBW251, NVP-QBW251) is an oral potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with EC50 of 79 nM and 497 nM for F508del CFTR and G551D CFTR in Fisher Rat Thyroid (FRT) cells.

Icenticaftor (QBW251) Chemical Structure

Icenticaftor (QBW251) Chemical Structure

CAS No. 1334546-77-8

Purity & Quality Control

Batch: S997201 DMSO]72 mg/mL]false]Ethanol]72 mg/mL]false]Water]Insoluble]false Purity: 99.89%
99.89

Icenticaftor (QBW251) Related Products

Signaling Pathway

CFTR Signaling Pathways

CFTR Signaling Pathway

Biological Activity

Description

Icenticaftor (QBW251, NVP-QBW251) is an oral potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with EC50 of 79 nM and 497 nM for F508del CFTR and G551D CFTR in Fisher Rat Thyroid (FRT) cells.
Targets
F508del CFTR [1] G551D CFTR [1]
79 nM(EC50) 497 nM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04396366 Terminated
Bronchiectasis
Novartis Pharmaceuticals|Innovative Medicines Initiative|Novartis
 February 2 2021 Phase 2
NCT04587622 Completed
Hepatic Failure
Novartis Pharmaceuticals|Novartis
 October 30 2020 Phase 1
NCT04268823 Terminated
Chronic Obstructive Pulmonary Disease
Novartis Pharmaceuticals|Novartis
 September 10 2020 Phase 2
NCT02449018 Completed
Chronic Obstructive Pulmonary Disease COPD
Novartis Pharmaceuticals|Novartis
 April 30 2015 Phase 2
NCT02190604 Terminated
Cystic Fibrosis
Novartis Pharmaceuticals|Novartis
 July 31 2012 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 361.24 Formula

C12H13F6N3O3
CAS No. 1334546-77-8 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 72 mg/mL ( (199.31 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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