Home PI3K/Akt/mTOR PI3K modulator - Akt modulator Homosalate For research use only.

Homosalate

Synonyms: HMS, Homomenthyl salicylate

Homosalate (HMS, Homomenthyl salicylate) is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways.

Homosalate Chemical Structure

Homosalate Chemical Structure

CAS No. 118-56-9

Purity & Quality Control

Homosalate Related Products

Signaling Pathway

PI3K Signaling Pathways

PI3K Signaling Pathway

Biological Activity

Description Homosalate (HMS, Homomenthyl salicylate) is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways.
In vitro
In vitro

Extracellular vesicles (EVs) released by Homosalate‐treated cells enhance resistance to anchorage loss in another recipient epithelial tumour cell line.[2]
Cell Research Cell lines MDA‐MB‐231 parental cells
Concentrations 10 μM
Incubation Time 24 h
Method

For EV isolation, 6 × 106 of MDA‐MB‐231 parental cells were seeded per 15 cm culture dish in an optimized number of dishes to obtain 70 × 106, 27 × 106 or 50 × 106 secreting cells. After 24 h, cells were washed 1 X with PBS and 15 ml of serum free, phenol red free Leibovitz's L‐15 were added. DMSO (0.1%), Homosalate (10 μM) or Bafilomycin A1 (100 nM) were added to phenol‐red free, serum‐free Leibovitz's L‐15 medium incubated on cells during 24 h (DMSO and Homosalate) or 16 h (Bafilomycin A1). The day after, cells were counted and the percentage of cell viability was determined using Trypan Blue.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04950543 Completed
Quality of Life
Charite University Berlin Germany
 July 5 2021 --
NCT04046952 Completed
Arterial Occlusion|Cardiovascular Diseases|Atherosclerosis|Hematoma|Anticoagulant-induced Bleeding|Coronary Artery Disease
VA Long Beach Healthcare System
 October 10 2019 Not Applicable
NCT04324424 Completed
Type 2 Diabetes Mellitus
Hua Medicine Limited
 April 23 2019 Phase 1
NCT04426708 Completed
Type 2 Diabetes Mellitus
Hua Medicine Limited
 February 18 2019 Phase 1
NCT03158506 Completed
Healthy Subject
Hua Medicine Limited
 March 29 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 262.34 Formula

C16H22O3
CAS No. 118-56-9 SDF --
Density 1.045 g/mL
Smiles CC1CC(CC(C)(C)C1)OC(=O)C2=C(O)C=CC=C2
Storage (From the date of receipt) 2 years -20°C liquid

In vitro
Batch:


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Homosalate | Homosalate supplier | purchase Homosalate | Homosalate cost | Homosalate manufacturer | order Homosalate | Homosalate distributor