FPH2 (BRD-9424)

Catalog No.S7452 Purity:99.83%

FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.

FPH2 (BRD-9424) Chemical Structure

CAS No. 957485-64-2

Purity & Quality Control

Batch: S745201 DMSO]70 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.83%

99.83

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Related Compound Libraries	Kinase Inhibitor Library FDA-approved Drug Library Stem Cell Signaling Compound Library GPCR Compound Library Stem Cell Differentiation Compound Library	Click to Expand

Biological Activity

Description	FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.

In vitro
In vitro	FPH2 induces functional proliferation of hepatocytes in vitro, and thus expands mature human primary hepatocytes. FPH2 may lead to the development of new therapeutics for liver diseases. ^[1]

References
[1] Shan J, et al. Nat Chem Biol. 2013, 9(8), 514-520.

References

[1] Shan J, et al. Nat Chem Biol. 2013, 9(8), 514-520.

Chemical Information & Solubility

Molecular Weight	353.83	Formula	C₁₄H₁₆ClN₅O₂S
CAS No.	957485-64-2	SDF	Download FPH2 (BRD-9424) SDF
Smiles	CCN1C=C(C(=N1)C(=O)N)NC(=S)NC2=C(C=CC(=C2)Cl)OC
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 70 mg/mL ( (197.83 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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