Home Endocrinology & Hormones Glucocorticoid Receptor agonist Fluticasone propionate For research use only.

Fluticasone propionate

Synonyms: CCI-187881

Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.

Fluticasone propionate Chemical Structure

Fluticasone propionate Chemical Structure

CAS No. 80474-14-2

Purity & Quality Control

Batch: S199201 DMSO]100 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.97%
99.97

Fluticasone propionate Related Products

Biological Activity

Description Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Targets
Glucocorticoid receptor [1]
In vitro
In vitro Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts. [1] Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation. [2] Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. [3]
In Vivo
In vivo Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06290102 Recruiting
Asthma
Teva Branded Pharmaceutical Products R&D Inc.
 May 2 2024 Phase 1
NCT02630121 Recruiting
Sleep Apnea|Chronic Nasal Congestion
University of South Florida
 April 2023 Phase 4
NCT05608681 Recruiting
Eosinophilic Esophagitis
Eupraxia Pharmaceuticals Inc.
 March 31 2023 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 500.57 Formula

C25H31F3O5S
CAS No. 80474-14-2 SDF Download Fluticasone propionate SDF
Smiles CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (199.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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