Eperisone hydrochloride

Name: Eperisone hydrochloride
Brand: Selleck Chemicals
SKU: S4877
Rating: 5 (1 reviews)

Catalog No.S4877 Purity:99.86%

Eperisone hydrochloride is muscle relaxant agent with antispasmodic effects. It is widely used in the treatment of patients with muscular contractures, low back pain or spasticity.

Eperisone hydrochloride Chemical Structure

CAS No. 56839-43-1

Purity & Quality Control

Batch: S487701 DMSO]59 mg/mL]false]]]false]]]false Purity: 99.86%

99.86

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Biological Activity

Description	Eperisone hydrochloride is muscle relaxant agent with antispasmodic effects. It is widely used in the treatment of patients with muscular contractures, low back pain or spasticity.

In Vivo
In vivo	Eperisone has very low bioavailability after oral administration in rats and extensively high oral clearance in humans. It undergoes extensive first-pass metabolism after oral administration in rats and humans because absorption of the drug is very high. The bioavailabilities in the intestine were 0.176 and 0.0879 at administration rates of 100 and 25 mg/h/kg, respectively, whereas those in the liver were 0.532 and 0.486, respectively. Eperisone has high metabolic clearance in the small intestine^[1].
Animal Research	Animal Models	Male Wistar rats
	Dosages	25 mg/h/kg
	Administration	infused from the femoral vein, portal vein and duodenum

References

[1] Mihara K, et al. Pharm Res. 2001, 18(8):1131-7

Chemical Information & Solubility

Molecular Weight	295.85	Formula	C₁₇H₂₅NO.HCl
CAS No.	56839-43-1	SDF	--
Smiles	CCC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 59 mg/mL ( (199.42 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

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