Home Metabolism Factor Xa inhibitor Edoxaban tosylate Monohydrate For research use only.

Edoxaban tosylate Monohydrate

Synonyms: DU-176b

Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

Edoxaban tosylate Monohydrate Chemical Structure

Edoxaban tosylate Monohydrate Chemical Structure

CAS No. 1229194-11-9

Purity & Quality Control

Edoxaban tosylate Monohydrate Related Products

Signaling Pathway

Factor Xa Signaling Pathways

Factor Xa Signaling Pathway

Biological Activity

Description Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.
Targets
Factor Xa [1]
(Cell-free assay)
0.561 nM(Ki)
In vitro
In vitro In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively. [1]
In Vivo
In vivo Oral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models. [1]
Animal Research Animal Models Venous stasis thrombosis model in rats and rabbits
Dosages 0.3–3 mg/kg (Rabbit); 0.5–12.5 mg/kg (Rat)
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05339672 Recruiting
Drug-drug Interaction
Radboud University Medical Center|Astellas Pharma Inc
 July 1 2024 --
NCT06326138 Withdrawn
Bariatric Surgery Candidate
Institut universitaire de cardiologie et de pneumologie de Québec University Laval
 March 11 2024 Phase 1
NCT05869591 Recruiting
Liver Cirrhosis
Centre Hospitalier Universitaire Vaudois
 January 18 2024 Phase 2
NCT06149533 Not yet recruiting
Thrombosis Venous|Cancer|Catheter Complications
Cancer Institute and Hospital Chinese Academy of Medical Sciences
 November 30 2023 Phase 3
NCT05804747 Recruiting
Atrial Fibrillation
Daiichi Sankyo|Daiichi Sankyo Korea Co. Ltd.
 February 16 2023 --

Chemical Information & Solubility

Molecular Weight 738.27 Formula

C24H30ClN7O4S.C7H8O3S.H2O
CAS No. 1229194-11-9 SDF Download Edoxaban tosylate Monohydrate SDF
Smiles CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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