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Doripenem

Synonyms: S 4661

Doripenem(S 4661) is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

Doripenem Chemical Structure

Doripenem Chemical Structure

CAS No. 148016-81-3

Purity & Quality Control

Batch: S553101 DMSO]60 mg/mL]false]]]false]]]false Purity: 98%
98

Doripenem Related Products

Biological Activity

Description Doripenem(S 4661) is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01366651 Terminated
Meningitis
Janssen Research & Development LLC
 March 2012 Phase 1
NCT01524302 Completed
Pneumonia Bacterial|Community-acquired
Gary E. Stein Pharm.D.|Forest Laboratories|Michigan State University
 February 2012 Phase 4
NCT01467648 Completed
Ventilator-Associated Pneumonia
Sutep Jaruratanasirikul|Prince of Songkla University
 October 2010 Phase 4
NCT01401010 Completed
Febrile Neutropenia
Gary E. Stein Pharm.D.|Michigan State University
 August 2010 Phase 4

Chemical Information & Solubility

Molecular Weight 420.50 Formula

C15H24N4O6S2
CAS No. 148016-81-3 SDF --
Smiles CC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 60 mg/mL ( (142.68 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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