Cyclen

Name: Cyclen
Brand: Selleck Chemicals
SKU: S4927
Rating: 5 (1 reviews)

Synonyms: 1,4,7,10-tetraazacyclododecane

Catalog No.S4927 Purity:99.97%

Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.

Cyclen Chemical Structure

CAS No. 294-90-6

Purity & Quality Control

Batch: S492701 DMSO]34 mg/mL]false]Water]34 mg/mL]false]Ethanol]34 mg/mL]false Purity: 99.97%

99.97

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ Express-Pick Library	Click to Expand

Biological Activity

Description	Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT01498861	Completed	Infection Human Immunodeficiency Virus	ViiV Healthcare\|Shionogi\|GlaxoSmithKline	December 2011	Phase 1
NCT01458210	Completed	Diabetes Mellitus Type 2	Eli Lilly and Company	October 2011	Phase 1
NCT01063023	Completed	Hepatitis C Virus	Bristol-Myers Squibb	January 2010	Phase 1
NCT01243580	Completed	Healthy	Agile Therapeutics	August 2009	Phase 1
NCT00901290	Suspended	Pharmacokinetics	AstraZeneca	May 2009	Phase 1

Chemical Information & Solubility

Molecular Weight	172.27	Formula	C₈H₂₀N₄
CAS No.	294-90-6	SDF	--
Smiles	C1CNCCNCCNCCN1
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 34 mg/mL ( (197.36 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 34 mg/mL

Ethanol : 34 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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