Cinacalcet

Synonyms: AMG073, Sensipar, Cin

Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.

Cinacalcet Chemical Structure

Cinacalcet Chemical Structure

CAS No. 226256-56-0

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Cinacalcet Related Products

Biological Activity

Description Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.
Targets
CaR [1]
In vitro
In vitro

Cinacalcet can activate CaSR and elicit an increase of atg7, becn and lc3a mRNA transcripts.[2]

Cell Research Cell lines human AT-derived (primary) preadipocytes
Concentrations 2 μM
Incubation Time 6 h
Method

Isolation of human AT-derived (primary) preadipocytes was performed. After passage 3 in culture with DMEM:F12 and 10% FBS, preadipocytes were switched to 2.5% FBS and exposed to cinacalcet, spermine and/or the upstream ERK (MAPK) inhibitor U0126, plus the autophagy flux inhibitor CQ for the last 2-3 h. CaSR activators were used for 6 h, while U0126 was used 1 h before exposure to the CaSR activator.

(Data sourced from selleck products)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06403618 Not yet recruiting
Cervical Intraepithelial Neoplasia Grade 2
European Institute of Oncology
May 15 2024 --
NCT06210854 Not yet recruiting
HPV Infection
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
May 2024 Phase 2
NCT06213051 Not yet recruiting
Human Papillomavirus Infection
Foundation for Innovative New Diagnostics Switzerland|Kenya Medical Research Institute|Frere Hospital East London South Africa
April 1 2024 --

Chemical Information & Solubility

Molecular Weight 357.41 Formula

C22H22F3N

CAS No. 226256-56-0 SDF --
Smiles CC(NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=CC=CC=C23
Storage (From the date of receipt) 2 years -20°C liquid

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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