Home Metabolism Lipase inhibitor Cetilistat For research use only.

Cetilistat

Synonyms: ATL962

Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo

Cetilistat Chemical Structure

Cetilistat Chemical Structure

CAS No. 282526-98-1

Purity & Quality Control

Batch: S493001 Ethanol]8 mg/mL]false]DMSO]3 mg/mL]false]Water]Insoluble]false Purity: 98.99%
98.99

Cetilistat Related Products

Biological Activity

Description Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo
Targets
human pancreatic lipase [1] rat pancreatic lipase [1]
5.95 nM 54.8 nM
In vitro
In vitro Cetilistat inhibits rat and human pancreatic lipase activity with an IC50 of 54.8 nM and 5.95 nM, respectively[1].
In Vivo
In vivo Cetilistat reduces intestinal fat absorption in rats and decreases energy intake without CNS side effects. Cetilistat ameliorates obesity and hyperlipidemia in DIO rats, a plausible animal model of the most common type of human obesity[1].
Animal Research Animal Models Male nine-week-old SD rats
Dosages 3, 10, 30, or 100 mg/kg
Administration oral administration
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00148382 Completed
Obesity
Alizyme
 April 2005 Phase 1

Chemical Information & Solubility

Molecular Weight 401.58 Formula

C25H39NO3
CAS No. 282526-98-1 SDF --
Smiles CCCCCCCCCCCCCCCCOC1=NC2=C(C=C(C=C2)C)C(=O)O1
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 8 mg/mL

DMSO : 3 mg/mL ( (7.47 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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