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Capreomycin Sulfate

Name: Capreomycin Sulfate
Brand: Selleck Chemicals
SKU: S4234
Rating: 5 (1 reviews)

Catalog No.S4234 Purity:99.31%

Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit.

Capreomycin Sulfate Chemical Structure

CAS No. 1405-37-4

Purity & Quality Control

Antibiotic Titer ≥700IU/mg
Cited in Nature Medicine for its top-tier quality
COA
Datasheet
SDS

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Biological Activity

Description	Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit.

In vitro
In vitro	Capreomycin anchors Cu(2+) ion with an amino function of the α,β-diaminopropionic acid residue at pH around 5.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT04239326	Completed	Tuberculosis Multidrug-Resistant	Foundation for Innovative New Diagnostics Switzerland	April 16 2021	--
NCT02496572	Unknown status	Multidrug Resistant Tuberculosis	Medecins Sans Frontieres Netherlands\|Ministry of Health Republic of Uzbekistan\|Imperial College London	September 2013	--
NCT02169141	Completed	Tuberculosis	University Medical Center Groningen\|Republican Scientific and Practical Centre for Pulmonology and TB\|National Institute for Public Health and the Environment (RIVM)	November 2012	--

References

[1] Stokowa K, et al. J Inorg Biochem, 2012, 106(1), 111-116.

Chemical Information & Solubility

Molecular Weight	750.78	Formula	C₂₅H₄₄N₁₄O₇.H₂SO₄
CAS No.	1405-37-4	SDF	Download Capreomycin Sulfate SDF
Smiles	C1CN=C(NC1C2C(=O)NCC(C(=O)NC(C(=O)NC(C(=O)NC(=CNC(=O)N)C(=O)N2)CNC(=O)C(CCCN)N)CO)N)N.OS(=O)(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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