Home Neuronal Signaling Adrenergic Receptor antagonist Buflomedil HCl For research use only.

Buflomedil HCl

Synonyms: NSC 759291

Buflomedil HCl(NSC 759291) is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.

Buflomedil HCl Chemical Structure

Buflomedil HCl Chemical Structure

CAS No. 35543-24-9

Purity & Quality Control

Buflomedil HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Buflomedil HCl(NSC 759291) is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor.
In vitro
In vitro

Buflomedil increases intracellular levels of cAMP in human keratinocytes, either secondary to phosphodiesterase inhibition (PTX) or adenyl-cyclase stimulation (BC). Buflomedil diminishes TPA-induced TNF-alpha and IL-8 release from keratinocytes; in the case of IL-8 it is possible that this inhibition occur to transcriptional level. [1] Buflomedil significantly inhibits epinephrine-induced aggregation at the micromolar level. Buflomedil results in a weak inhibition of ADP- and collagen-induced aggregation. Buflomedil inhibits granular secretion and the interaction of fibrinogen with its receptor on platelet. [2] Buflomedil hypochloride improves the capillary perfusion in such related situations, evoking a possible effect upon neutrophils. Buflomedil decreases 100% of histamine related neutrophil adhesion (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil decreases the expression of P-selectin at the surface of endothelial cells and hypoxia induced neutrophil adhesion. [3]
In Vivo
In vivo

Buflomedil (6 mg/kg) increases flap survival in nicotine treated rats. [4] Buflomedil (3 mg/kg) significantly reduces both post-ischemic capillary perfusion failure and leukocyte adherence in venules. [5] Buflomedil reduces the vasodilation evoked by phentolamine and potentiates its depressive effect on vasomotion frequency and amplitude in the hamster cheek pouch. [6]

Chemical Information & Solubility

Molecular Weight 343.85 Formula

C17H25NO4.HCl
CAS No. 35543-24-9 SDF Download Buflomedil HCl SDF
Smiles COC1=CC(=C(C(=C1)OC)C(=O)CCCN2CCCC2)OC.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 69 mg/mL

DMSO : 31 mg/mL ( (90.15 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 7 mg/mL


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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