Home Microbiology Bacterial chemical Amikacin disulfate For research use only.

Amikacin disulfate

Synonyms: BB-K8

Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.

Amikacin disulfate Chemical Structure

Amikacin disulfate Chemical Structure

CAS No. 39831-55-5

Purity & Quality Control

Batch: S306501 Water]10 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.68%
99.68

Amikacin disulfate Related Products

Biological Activity

Description Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.
Targets
16S rRNA [1]
In vitro
In vitro Amikacin sulfate has high affinities for 16S rRNA of the bacterial 30S ribosome, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. [1] Amikacin is active in vitro against Pseudomonas species, [2] Escherichia coli[3], Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii.[4] [5] In vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms. [6]
In Vivo
In vivo Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective than the twice-daily regimen. [7] Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increased the activity significantly. [8]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05555303 Recruiting
Tuberculosis Multidrug-Resistant
Rwanda Biomedical Centre|Institute of Tropical Medicine|World Health Organization
 March 1 2023 Phase 2
NCT05689450 Completed
Febrile Neutropenia (FN)
University Hospital Basel Switzerland
 December 21 2022 --
NCT05593601 Recruiting
Colonization Asymptomatic
Mahidol University
 November 24 2022 Phase 4
NCT05511129 Active not recruiting
COVID-19|Nosocomial Infection
Fondation Hôpital Saint-Joseph
 May 12 2022 --
NCT04239326 Completed
Tuberculosis Multidrug-Resistant
Foundation for Innovative New Diagnostics Switzerland
 April 16 2021 --

Chemical Information & Solubility

Molecular Weight 781.76 Formula

C22H43N5O13.2H2SO4
CAS No. 39831-55-5 SDF Download Amikacin disulfate SDF
Smiles C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 10 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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