Home Neuronal Signaling Serotonin Transporter inhibitor Venlafaxine HCl For research use only.

Venlafaxine HCl

Synonyms: Wy 453 HCl

Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

Venlafaxine HCl Chemical Structure

Venlafaxine HCl Chemical Structure

CAS No. 99300-78-4

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Venlafaxine HCl Related Products

Biological Activity

Description Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
Targets
5-HT [1]
In vitro
In vitro

Venlafaxine has a low potential to inhibit the metabolism of substrates for CYP2D6 such as imipramine and desipramine compared with several of the most widely used SSRIs, as well as the metabolism of substrates for several of the other major human hepatic P450s. [1] Venlafaxine inhibits binding to the human norepinephrine (NE) and serotonin (5-HT) transporters with K(i) values of 2480 nM and 82 nM, respectively, and with a K(i) ratio of 30. Venlafaxine has ED(50) values of 5.9 mg/kg and 94 mg/kg for blocking p-chloramphetamine- and 6-hydroxydopamine-induced monoamine depletion, respectively. [2]
In Vivo
In vivo

Venlafaxine induces a dose-dependent antinociceptive effect following i.p. administration with an ED50 of 46.7 mg/kg in mice. Venlafaxine-induced antinociception is significantly inhibited by naloxone, nor-BNI and naltrindole but not by beta-FNA or naloxonazine, implying involvement of kappa1- and delta-opioid mechanisms in mice. [3] Venlafaxine reverses hyperalgesia in rats with a fully developed neuropathic lesion. Venlafaxine also appears to have a mild non-specific analgesic effect that increased paw withdrawal latency (PWL) in the sham limb. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06131268 Recruiting
Major Depressive Disorder|Bipolar Affective Disorder Currently Depressed Moderate
Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico
 March 1 2022 Phase 4
NCT04708834 Enrolling by invitation
Obsessive Compulsive Disorder
Biohaven Pharmaceuticals Inc.
 March 30 2021 Phase 3
NCT03532477 Recruiting
Obesity Morbid
Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital
 November 2 2016 --
NCT02637193 Completed
Healthy Subjects
Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer
 December 2015 Phase 1
NCT02005107 Completed
Roux en Y Gastric Bypass|Sleeve Gastrectomy
North Dakota State University|Neuropsychiatric Research Institute Fargo North Dakota
 December 2013 Phase 4
NCT01867255 Completed
Bariatric Surgery|Gastric Bypass|Roux-en-Y Gastric Bypass
Mayo Clinic
 October 2013 Phase 1

Chemical Information & Solubility

Molecular Weight 313.86 Formula

C17H27NO2·HCl
CAS No. 99300-78-4 SDF Download Venlafaxine HCl SDF
Smiles CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 63 mg/mL ( (200.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 63 mg/mL

Ethanol : 63 mg/mL


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In vivo
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