Home NF-κB NF-κB chemical Vanillylacetone For research use only.

Vanillylacetone

Synonyms: NSC 15335

Vanillylacetone (NSC 15335) is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Vanillylacetone (Zingerone) alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.

Vanillylacetone Chemical Structure

Vanillylacetone Chemical Structure

CAS: 122-48-5

Purity & Quality Control

Batch: S237101 DMSO] 38 mg/mL] false] Ethanol] 38 mg/mL] false] Water] 10 mg/mL] false Purity: 99.89%
99.89

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Signaling Pathway

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Biological Activity

Description Vanillylacetone (NSC 15335) is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Vanillylacetone (Zingerone) alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.
Targets
NF-κB [2]
In vitro
In vitro

Vanillylacetone is similar in chemical structure to other flavor chemicals such as vanillin and eugenol. It is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Fresh ginger does not contain vanillylacetone; cooking the ginger transforms gingerol, which is present, into vanillylacetone through a retro-aldol reaction. Vanillylacetone is likely the active constituent responsible for the antidiarrheal efficacy of ginger. [1]

Chemical Information & Solubility

Molecular Weight 194.23 Formula

C11H14O3
CAS No. 122-48-5 SDF Download Vanillylacetone SDF
Smiles CC(=O)CCC1=CC(=C(C=C1)O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 38 mg/mL ( (195.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 38 mg/mL

Water : 10 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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