Home GPCR & G Protein Adrenergic Receptor agonist Phenylephrine HCl For research use only.

Phenylephrine HCl

Synonyms: NCI-C55641 HCl,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride

Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.

Phenylephrine HCl Chemical Structure

Phenylephrine HCl Chemical Structure

CAS No. 61-76-7

Purity & Quality Control

Phenylephrine HCl Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.
Targets
α1-adrenergic receptor [1]
In vitro
In vitro

Phenylephrine causes a rapid translocation of PKC-epsilon (EC50 = 0.9 mM) but the proportion lost from the soluble fraction is less than with ET-1. [1] Phenylephrine at pCa 7 causes a dose-dependent increase in contractile force of the hyperpermeable cells, which is reversible on addition of phentolamine. [2] Phenylephrine also protects cardiomyocytes against subsequent 24 h treatment with hypoxia and serum deprivation. Phenylephrine prevents the down-regulation of Bcl-2 and Bcl-X mRNA/protein and induces hypertrophic growth. Phenylephrine-mediated protection is abrogated by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin and is mimicked by the caspase-9 peptidic inhibitor LEHD-fmk. [3] Phenylephrine stimulates phosphoinositide (PI) hydrolysis, cell growth, and expression of several genes [e.g., atrial natriuretic factor (ANF)] often associated with cardiac hypertrophy. [4] Phenylephrine (1 礛) markedly potentiates HGF-induced hepatocyte DNA synthesis and proliferation. [5] Phenylephrine (10 mM) reversibly increases I(Ca,L) (51.3%; n = 40) and shifted peak I(Ca,L) activation voltage by -10 mV. Phenylephrine also increases local, subsarcolemmal SR Ca2+ release via IP3-dependent signaling. Phenylephrin-induced NOi release requires stimulation of both PI-3K/Akt and IP3-dependent Ca2+ signaling. Phenylephrine-induced NOi release is inhibited by each of 1 mM prazocin, 10 mM L-NIO, 10 mM W-7, 10 mM LY294002, 2 mM H-89, 10 mM ryanodine, 5 mM thapsigargin, 2 mM 2-APB or 10 mM xestospongin C. [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06220942 Recruiting
Anesthesia
Ain Shams University
 October 5 2023 --
NCT05935657 Not yet recruiting
Remimazolam|Spinal Anesthesia
Pusan National University Yangsan Hospital
 August 2023 Not Applicable
NCT05651399 Recruiting
Remimazolam|Propofol|Orthopedic Procedures|Sedatives|Anesthesia Spinal
Asan Medical Center
 December 26 2022 Phase 4

Chemical Information & Solubility

Molecular Weight 203.67 Formula

C9H13NO2.HCl
CAS No. 61-76-7 SDF Download Phenylephrine HCl SDF
Smiles CNCC(C1=CC(=CC=C1)O)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 41 mg/mL ( (201.3 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 41 mg/mL

Ethanol : 41 mg/mL


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In vivo
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