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Omeprazole

Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.

Omeprazole Chemical Structure

Omeprazole Chemical Structure

CAS No. 73590-58-6

Purity & Quality Control

Omeprazole Related Products

Signaling Pathway

Proton Pump Signaling Pathways

Proton Pump Signaling Pathway

Biological Activity

Description Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.
Targets
Proton pump [1] H(+)-K(+)-ATPase [1]
In vitro
In vitro Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. [1] Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. [2] Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect. [3]
In Vivo
In vivo Omeprazole blocks H(+)-K(+)-ATPase, thus enhances degeneration and macrophage-mediated elimination of parietal cells and also causes an increase in preparietal cell production. Omeprazole temporarily changes the dynamic features of parietal cells in the rabbit to make them die early and grow fast. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06378398 Not yet recruiting
Colorectal Neoplasia
University of Michigan Rogel Cancer Center|National Cancer Institute (NCI)
 May 2024 Early Phase 1
NCT05671653 Terminated
Obesity
Pfizer
 January 19 2023 Phase 1
NCT05635110 Completed
Pain
Vertex Pharmaceuticals Incorporated
 December 15 2022 Phase 1
NCT05651074 Recruiting
Healthy Subjects
Jiangsu vcare pharmaceutical technology co. LTD
 November 14 2022 Phase 1

Chemical Information & Solubility

Molecular Weight 345.42 Formula

C17H19N3O3S
CAS No. 73590-58-6 SDF Download Omeprazole SDF
Smiles CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 69 mg/mL ( (199.75 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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