Home Neuronal Signaling AChR inhibitor Neostigmine Bromide For research use only.

Neostigmine Bromide

Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.

Neostigmine Bromide Chemical Structure

Neostigmine Bromide Chemical Structure

CAS No. 114-80-7

Purity & Quality Control

Neostigmine Bromide Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
Targets
AChR [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06136585 Not yet recruiting
Neuromuscular Blocks
The Cleveland Clinic|Merck Sharp & Dohme LLC
 May 15 2024 Not Applicable
NCT05943613 Not yet recruiting
Postoperative Pain
Assiut University
 December 1 2023 Phase 1
NCT05794503 Recruiting
Urinary Retention Postoperative|Laparoscopic Cholecystectomy|Neuromuscular Blockade|Sugammadex|Neostigmine|Neuromuscular Blocking Agents|Physiological Effects of Drugs
University of Texas Southwestern Medical Center
 September 11 2023 Early Phase 1
NCT04570150 Completed
Anesthesia
University of California San Diego
 January 4 2021 Phase 4

Chemical Information & Solubility

Molecular Weight 303.2 Formula

C12H19N2O2.Br
CAS No. 114-80-7 SDF Download Neostigmine Bromide SDF
Smiles CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

Water : 60 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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