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Sodium Monensin (NSC 343257) Antineoplastic and Immunosuppressive Antibiotics chemical

Name: Sodium Monensin (NSC 343257)
Brand: Selleck Chemicals
SKU: S2324
Availability: InStock
Rating: 5 (16 reviews)

Cat.No.S2324

Sodium Monensin (NSC 343257), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.

Chemical Structure

Molecular Weight: 692.85

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: Purity: >97%

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Chemical Information, Storage & Stability

Molecular Weight	692.85	Formula	C₃₆H₆₁NaO₁₁	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	22373-78-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)[O-])OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C.[Na+]

Solubility

In vitro
Batch:

Ethanol : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li⁺, Na⁺, K⁺, Rb⁺, Ag⁺, and TI⁺. ^[1] Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na⁺/H⁺ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. ^[2] The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes. ^[3]
In vivo	LD50: Mice 335mg/kg (i.g.) ^[4]; Rats 36.5mg/kg (i.g.); Chickens 185mg/kg (i.g.). ^[5]
References	[1] https://pubmed.ncbi.nlm.nih.gov/5453344/ [2] https://pubmed.ncbi.nlm.nih.gov/2160275/ [3] https://pubmed.ncbi.nlm.nih.gov/18375122/

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