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Linezolid (PNU-100766)

Name: Linezolid (PNU-100766)
Brand: Selleck Chemicals
SKU: S1408
Rating: 5 (21 reviews)

Catalog No.S1408 Purity:99.99%

Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.

Linezolid (PNU-100766) Chemical Structure

CAS No. 165800-03-3

Purity & Quality Control

Batch: Purity: 99.99%

99.99

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Biological Activity

Description	Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.

In vitro
In vitro	Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Linezolid inhibits complex formation with Staphylococcus aureus 70S tight-couple ribosomes. ^[1] Linezolid is a potent inhibitor of cell-free transcription-translation in E. coli, exhibiting 50% inhibitory concentrations (IC50s) of 1.8 mM. ^[2] Linezolid is an oxazolidinone, a new class of antibacterial agents with enhanced activity against pathogens. ^[3] Linezolid MICs vary slightly with the test method, laboratory, and significance attributed to thin hazes of bacterial survival, but all workers find that the susceptibility distributions are narrow and unimodal, with MIC values between 0.5 and 4 mg/L for streptococci, enterococci and staphylococci. Linezolid entails mutation of the 23S rRNA that forms the binding site. ^[4] Linezolid is an oxazolidinone whose mechanism of action involves inhibition of protein synthesis at a very early stage. Linezolid is added to 7H10 agar medium (Difco) supplemented with OADC (oleic acid, albumin, dextrose, and catalase) at 50°C to 56°C by doubling the dilutions to yield a final concentration of 0.125 μg/mL to 4 μg/mL. Linezolid shows excellent in vitro activity against all the strains tested (MICs ≤ 1 μg/ml), including those resistant to SIRE. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05944445	Recruiting	Thrombocytopenia; Drugs	Helwan University	July 13 2023	--
NCT05571722	Not yet recruiting	Antibiotic Prophylaxis\|General Surgery	Assistance Publique Hopitaux De Marseille	April 3 2023	Phase 4
NCT06291181	Completed	Staphylococcus Aureus	Sohag University	January 1 2023	Not Applicable
NCT05381194	Recruiting	Multidrug- and Rifampicin-resistant Tuberculosis	Asan Medical Center\|Pusan National University Hospital\|Samsung Medical Center\|Seoul National University Hospital\|Severance Hospital\|Chonnam National University Hospital\|The Catholic University of Korea\|Chungbuk National University Hospital\|Ulsan University Hospital\|Soon Chun Hyang University\|Incheon St.Mary''s Hospital\|DongGuk University\|National Medical Center Seoul	December 13 2022	Phase 4
NCT05801484	Recruiting	Side-effect of Antibiotic\|Efficacy\|Pharmacokinetics\|Critical Illness\|Intensive Care Unit ICU	Cluj Municipal Clinical Hospital\|Iuliu Hatieganu University of Medicine and Pharmacy	July 1 2022	Not Applicable

References

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Chemical Information & Solubility

Molecular Weight	337.35	Formula	C₁₆H₂₀FN₃O₄
CAS No.	165800-03-3	SDF	Download Linezolid (PNU-100766) SDF
Smiles	CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 68 mg/mL ( (201.57 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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