Gadodiamide Hydrate

Catalog No.S1751 Purity:99.08%

Gadodiamide Hydrate, a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast.

Gadodiamide Hydrate Chemical Structure

CAS No. 122795-43-1

Purity & Quality Control

Batch: Purity: 99.08%

99.08

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Biological Activity

Description	Gadodiamide Hydrate, a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast.

In Vivo
In vivo	Gadodiamide results in half-life of 18, 38, and 75 minutes in rats, rabbits, and monkeys, respectively. Gadodiamide is shown to be excreted rapidly, primarily through the kidneys. ^[1] Gadodiamide, when administered i.v. as gadodiamide injection at a dosage of 0.3 mmol/kg, is stable in vivo and that the very major part of the dose (> 99%) is excreted in urine as an unchanged complex. ^[2] Gadodiamide produces focal and generalized myoclonus over several hours. Gadodiamide itself produces lesions in the central cerebellar regions resembling in character and severity those produced by the gadodiamide formulation, but not others. ^[3] Gadodiamide travels quickly throughout the ventricular system from the lateral ventricular site of injection to the fourth ventricle and foramina of Luschka and Magendie within 2 min. ^[4] Gadodiamide results in transient but statistically significant decreases in aortic pressure, left ventricular pressure, indices of left ventricular contractility and relaxation, and systemic and pulmonary vascular resistance, and increases in aortic blood flow in anesthetized dogs. Gadodiamide injection produces less severe alterations in hemodynamics than gadopentetate dimeglumine. ^[5]

References
[1] Harpur ES, et al. Invest Radiol, 1993, 28, S28-43. [2] Normann PT, et al. Eur J Drug Metab Pharmacokinet, 1995, 20(4), 307-313. [3] Ray DE, et al. AJNR Am J Neuroradiol, 1998, 19(8), 1455-1462. [4] Bui JD, et al. Neuroscience, 1999, 90(3), 1115-1122. [5] Peters JL, et al. Acta Radiol, 1993, 34(5), 510-516. + Expand

References

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Chemical Information & Solubility

Molecular Weight	591.67	Formula	C₁₆H₂₈GdN₅O₉C₁₆H₂₈GdN₅O₉.xH₂O
CAS No.	122795-43-1	SDF	Download Gadodiamide Hydrate SDF
Smiles	CNC(=O)CN(CCN(CCN(CC(=O)NC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].O.[Gd+3]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

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In vivo
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