Home Metabolism P450 (e.g. CYP17) inhibitor Diosmetin For research use only.

Diosmetin

Synonyms: Luteolin 4-methyl ether

Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants.

Diosmetin Chemical Structure

Diosmetin Chemical Structure

CAS No. 520-34-3

Purity & Quality Control

Diosmetin Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Biological Activity

Description Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants.
Targets
CYP1A1 [1]
In vitro
In vitro Diosmetin inhibits 3H-dopamine uptake in neuroblastoma cells, as well as in small-cell lung carcinoma cells, which is be responsible for the increased vascular tone observed in vivo after treatment with Diosmetin. [1] Moreover, Diosmetin also removes iron from iron-loaded hepatocytes revealed a good relationship between this iron-chelating ability and the cytoprotective effect. [2] Other studies proves that Diosmetin is a cytochrome P450 inhibitor, thus inhibiting carcinogen activation and and causing pharmacokinetic interactions with co-administered drugs metabolized. [3] [4]

Chemical Information & Solubility

Molecular Weight 300.26 Formula

C16H12O6
CAS No. 520-34-3 SDF Download Diosmetin SDF
Smiles COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 60 mg/mL ( (199.82 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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