Home Transmembrane Transporters Calcium Channel inhibitor Diltiazem HCl For research use only.

Diltiazem HCl

Synonyms: RG 83606 HCl

Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

Diltiazem HCl Chemical Structure

Diltiazem HCl Chemical Structure

CAS No. 33286-22-5

Purity & Quality Control

Diltiazem HCl Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
Targets
Calcium channel [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04777045 Active not recruiting
Microvascular Angina|Coronary Vasospasm|Microvascular Ischemia of Myocardium
Radboud University Medical Center
 October 25 2019 Phase 3

Chemical Information & Solubility

Molecular Weight 450.98 Formula

C22H26N2O4S.HCl
CAS No. 33286-22-5 SDF Download Diltiazem HCl SDF
Smiles CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 90 mg/mL ( (199.56 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 90 mg/mL

Ethanol : 4 mg/mL


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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