Home Metabolism Decarboxylase inhibitor Carbidopa For research use only.

Carbidopa

Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.

Carbidopa Chemical Structure

Carbidopa Chemical Structure

CAS No. 28860-95-9

Purity & Quality Control

Carbidopa Related Products

Biological Activity

Description Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.
Targets
aromatic-L-amino-acid decarboxylase [1]
29 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05909267 Recruiting
Depressive Disorder Major
Charite University Berlin Germany|Prof. Dr. Stefan M. Gold|Prof. Dr. Soyoung Q Park|Dr. Ulrike Grittner|Motognosis GmbH
 July 26 2023 Not Applicable
NCT05094050 Completed
Parkinson''s Disease
AbbVie
 January 18 2022 Phase 1
NCT05128175 Unknown status
Parkinson Disease
Shanghai WD Pharmaceutical Co. Ltd.
 October 29 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 226.23 Formula

C10H14N2O4
CAS No. 28860-95-9 SDF Download Carbidopa SDF
Smiles CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 4 mg/mL ( (17.68 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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