Home GPCR & G Protein Prostaglandin Receptor agonist Bimatoprost For research use only.

Bimatoprost

Synonyms: AGN 192024

Bimatoprost(AGN 192024) is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

Bimatoprost Chemical Structure

Bimatoprost Chemical Structure

CAS No. 155206-00-1

Purity & Quality Control

Bimatoprost Related Products

Biological Activity

Description Bimatoprost(AGN 192024) is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
In vitro
In vitro

Bimatoprost mildly stimulates the rate of aqueous humor flow during the day (13%) and at night (14%), its ocular hypotensive action is due primarily to a 26% reduction in the tonographic resistance to outflow. Bimatoprost enhances the pressure-sensitive outflow pathway. [1] Bimatoprost displaces [3H]prostaglandin F(2alpha) from FP receptors with K(i) of 6.31 μM. Bimatoprost rapidly mobilizes intracellular Ca(2+) via cloned human FP receptors expressed in human embryonic kidney cells and via native FP receptors in 3T3 mouse fibroblasts with EC(50) of 2.94 μM and 2.2 μM. [2] Bimatoprost up-regulates Cyr61 mRNA expression in the cat iris. Bimatoprost-induced up-regulation of Cyr61 mRNA expression is not because of the activation of the prostaglandin FP receptor but a different receptor. [3] Bimatoprost consistently evokes responses in different cells within the same tissue preparation, whereas prostaglandin F(2 alpha) and 17-phenyl prostaglandin F(2 alpha) elicites signaling responses in the same cells. Bimatoprost selectively stimulates intracellular calcium signaling in different cat iris sphincter cells. [4]
In Vivo
In vivo

Bimatoprost is the ethyl amide derivative of 17-phenyl trinor PGF2α, a potent prostaglandin FP receptor agonist. Bimatoprost elicits an immediate, robust spike in [Ca2+] that rapidly decayes back to baseline levels. Bimatoprost possess direct agonist activities at the rat, mouse, and human FP prostanoid receptor. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05729594 Completed
Healthy Volunteers
Laboratoires Thea
 February 27 2023 Phase 1
NCT04647214 Recruiting
Open-angle Glaucoma|Ocular Hypertension
Allergan
 March 3 2021 --
NCT04285580 Completed
Open-Angle Glaucoma|Ocular Hypertension
AbbVie
 June 11 2020 Phase 3
NCT03891446 Enrolling by invitation
Open-Angle Glaucoma|Ocular Hypertension
AbbVie
 March 27 2019 Phase 3

Chemical Information & Solubility

Molecular Weight 415.57 Formula

C25H37NO4
CAS No. 155206-00-1 SDF Download Bimatoprost SDF
Smiles CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (199.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 83 mg/mL

Water : Insoluble


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In vivo
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