Home Cytoskeletal Signaling ADC Cytotoxin inhibitor - Microtubule Associated inhibitor Albendazole For research use only.

Albendazole

Synonyms: SKF-62979

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

Albendazole Chemical Structure

Albendazole Chemical Structure

CAS No. 54965-21-8

Purity & Quality Control

Albendazole Related Products

Biological Activity

Description Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
Targets
tubulin [1]
In vitro
In vitro Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. [1]
In Vivo
In vivo Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. [2] Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. [3] Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. [4] Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06201559 Completed
Intestinal Diseases
GlaxoSmithKline
 August 21 2023 Phase 1
NCT05453045 Not yet recruiting
Pharmacological Action
Universidad Nacional de Salta|Fundacion Mundo Sano
 July 18 2022 Not Applicable

Chemical Information & Solubility

Molecular Weight 265.33 Formula

C12H15N3O2S
CAS No. 54965-21-8 SDF Download Albendazole SDF
Smiles CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 17 mg/mL ( (64.07 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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