Home Metabolism Carbohydrate Metabolism chemical Acarbose For research use only.

Acarbose

Synonyms: BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421

Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.

Acarbose Chemical Structure

Acarbose Chemical Structure

CAS No. 56180-94-0

Purity & Quality Control

Acarbose Related Products

Biological Activity

Description Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.
Targets
alpha-glucosidase [1]
In vitro
In vitro

Acarbose reversibly inhibits intestinal alpha-glucosidases, enzymes responsible for the metabolism of complex carbohydrates into absorbable monosaccharide units.[1]
In Vivo
In vivo

Acarbose reduces the absorption of monosaccharides derived from dietary carbohydrates, which play an important role in the metabolism and toxicity of some chemical compounds. Acarbose alone potentiates carbon tetrachloride (CCl4) andacetaminophen (AP) hepatotoxicity, as evidenced by significantly increased levels of both alanine transaminase (ALT) and aspartate transaminase (AST) in the plasma of rats pretreated with acarbose. [2] Acarbose treatment suppresses weight gain and the development of hepatic steatosis in sqstm1 gene knockout mice. Acarbose treatment up-regulates hepatic expression of the pparalpha, ucp-2, and abca1 genes, as well as srebp1c, pparalpha, and ppargamma in adipose tissue. [3] Acarbose-treated rats have lower body weights at 3 months of age with unaltered food consumption, and a similar effect is seen with a high-fructose diet in the JCR:LA-corpulent rat. [4] Acarbose markedly improves postprandial hyperglycemia, postprandial insulin level, total cholesterol, triglyceride, and free fatty acid level in Goto-Kakizaki (GK) rats. Acarbose efficiently reduces the number of monocytes adherent to aortic endothelial layer, improves acetylcholine-dependent vasodilatation, and reduces intimal thickening of the aorta in GK rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05487859 Not yet recruiting
Kidney Cancer
University of Alabama at Birmingham
 October 5 2025 Phase 2
NCT04665570 Active not recruiting
Type 2 Diabetes Mellitus
Bayer
 December 21 2020 --
NCT04180813 Terminated
Diabetes Mellitus Type 2
Boehringer Ingelheim
 March 4 2020 --
NCT02953093 Completed
Aging
Montefiore Medical Center
 August 30 2017 Phase 2
NCT02589353 Completed
Healthy Volunteers
Oregon State University
 April 21 2017 Phase 4
NCT02527239 Unknown status
Pompe''s Disease
Royal Brompton & Harefield NHS Foundation Trust|Genzyme a Sanofi Company
 September 2015 --

Chemical Information & Solubility

Molecular Weight 645.6 Formula

C25H43NO18
CAS No. 56180-94-0 SDF Download Acarbose SDF
Smiles CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)NC4C=C(C(C(C4O)O)O)CO
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 129 mg/mL ( (199.81 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 129 mg/mL

Ethanol : 8 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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