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6-Methylcoumarin

Synonyms: Toncarine

6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.

6-Methylcoumarin Chemical Structure

6-Methylcoumarin Chemical Structure

CAS No. 92-48-8

Purity & Quality Control

Batch: S480201 DMSO]32 mg/mL]false]]]false]]]false Purity: 99.99%
99.99

6-Methylcoumarin Related Products

Biological Activity

Description 6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.
In vitro
In vitro Transport experiments with Caco-2 cells show that 6-Methylcoumarin presents high permeability at all concentrations evaluated. This finding suggests that 6-Methylcoumarin could be transported across the gut wall by passive diffusion[1].
In Vivo
In vivo The plasma concentration-time curve shows that the maximum concentration (Cmax) is 17.13 ± 2.90 µg/mL at maximum time (Tmax) of 30 min for the oral route (200 mg/kg) and Cmax 26.18 ± 2.47 µg/mL at 6.0 min for the intraperitoneal administration (200 mg/kg), with elimination constant of (Ke) 0.0070/min and a short life half time of (T1/2) lower that 120 min. 6-Methylcoumarin has high accumulation in the liver, and widespread distribution in all the organs evaluated. The oral bioavailability (F) of 6-Methylcoumarin is 45% in Wistar rats[1].
Animal Research Animal Models Male Wistar rats
Dosages 200 mg/kg
Administration by oral gavage (p.o.) or intraperitoneal (i.p.) route

Chemical Information & Solubility

Molecular Weight 160.17 Formula

C10H8O2
CAS No. 92-48-8 SDF --
Smiles CC1=CC2=C(C=C1)OC(=O)C=C2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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