Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor 5-methoxyflavone For research use only.

5-methoxyflavone

5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.

5-methoxyflavone Chemical Structure

5-methoxyflavone Chemical Structure

CAS No. 42079-78-7

Purity & Quality Control

Batch: S478201 DMSO]50 mg/mL]false]]]false]]]false Purity: 99.83%
99.83

5-methoxyflavone Related Products

Signaling Pathway

DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway

Biological Activity

Description 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
Targets
DNA polymerase β [1]
In vitro
In vitro The treatment with 5-methoxyflavone (5-MF） at various times (3, 6, 12, 18 and 24 h) in MOLT-4 cells results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner[2].
Cell Research Cell lines human leukemic MOLT-4, U937 cell lines and PBMCs
Concentrations 0-100 μg/ml
Incubation Time 24 h
Method MOLT-4 or U937 or PBMC cells are treated with DMF or TMF or PMF, 5-MF or 2'-MF at various concentrations for 24 h, then the cell viability is determined by the MTT assay.

Chemical Information & Solubility

Molecular Weight 252.26 Formula

C16H12O3
CAS No. 42079-78-7 SDF Download 5-methoxyflavone SDF
Smiles COC1=CC=CC2=C1C(=O)C=C(O2)C3=CC=CC=C3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 50 mg/mL ( (198.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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