4-Methylbenzylidene camphor

Name: 4-Methylbenzylidene camphor
Brand: Selleck Chemicals
SKU: S3704
Rating: 5 (1 reviews)

Synonyms: Enzacamene, 4-MBC

Catalog No.S3704 Purity:99.96%

4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.

4-Methylbenzylidene camphor Chemical Structure

CAS No. 36861-47-9

Purity & Quality Control

Batch: S370401 DMSO]50 mg/mL]false]Ethanol]50 mg/mL]false]Water]Insoluble]false Purity: 99.96%

99.96

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Biological Activity

Description	4-Methylbenzylidene camphor (Enzacamene, 4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.

In Vivo
In vivo	Though 4MBC is weakly estrogenic in the reproductive system of fishes and rodents it shows strong anti-osteoporotic effects comparable to E2 after chronic application. 4MBC is resorbed through the skin after dermal administration resulting in identical biotransformation of this UV filter in humans and rats. 4MBC is a potent inhibitor of the pituitary-thyroid-axis^[1]. 4-MBC prevents bone loss and exerted a very weak estrogenic effect on the uterus and the vagina after a 3-month treatment of Ovx rats. 4-MBC exerts a positive effect on the mitochondria and microstructure of the skeletal muscle during the early stage of osteoporotic fracture healing^[2].

References

Chemical Information & Solubility

Molecular Weight	254.37	Formula	C₁₈H₂₂O
CAS No.	36861-47-9	SDF	Download 4-Methylbenzylidene camphor SDF
Smiles	CC1=CC=C(C=C1)C=C2C3CCC(C2=O)(C3(C)C)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 50 mg/mL ( (196.56 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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