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Tanespimycin (17-AAG)
Synonyms: CP127374, NSC-330507, KOS 953
Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.
Tanespimycin (17-AAG) Chemical Structure
CAS No. 75747-14-7
Purity & Quality Control
Batch:
Purity:
99.92%
99.92
Tanespimycin (17-AAG) Related Products
| Related Targets | HSP40 HSP70 HSP90 HSP105 HSF1 | Click to Expand |
|---|---|---|
| Related Products | Luminespib (NVP-AUY922) Elesclomol (STA-4783) Ganetespib (STA-9090) Alvespimycin (17-DMAG) HCl VER155008 BIIB021 Onalespib (AT13387) NVP-BEP800 KRIBB11 SNX-2112 HA15 Zelavespib (PU-H71) HSP990 (NVP-HSP990) NMS-E973 Apoptozole XL888 PF-04929113 (SNX-5422) KNK437 Teprenone TRC051384 VER-50589 Rocaglamide VER-49009 Pimitespib (TAS-116) JG98 DTHIB KW-2478 | Click to Expand |
| Related Compound Libraries | Kinase Inhibitor Library Angiogenesis Related compound Library TGF-beta/Smad compound library Cytoskeletal Signaling Pathway Compound Library Anti-Cardiovascular Disease Compound Library | Click to Expand |
Signaling Pathway
Cell Data
| Cell Lines | Assay Type | Concentration | Incubation Time | Formulation | Activity Description | PMID |
|---|---|---|---|---|---|---|
| A549 | Growth Inhibition Assay | IC50=0.000303 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.000407 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.00207 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=0.00209 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=0.00304 μM | SANGER | |||
| D-566MG | Growth Inhibition Assay | IC50=0.0039 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.00419 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.0051 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.00717 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=0.00929 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.01009 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.01355 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=0.01405 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.01495 μM | SANGER | |||
| TI-73 | Growth Inhibition Assay | IC50=0.01796 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=0.01938 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=0.01974 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=0.02249 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.02251 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.02261 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.02349 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=0.02494 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.02531 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=0.02546 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=0.02593 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=0.02628 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=0.02665 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=0.02786 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=0.02891 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.02999 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=0.03077 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.03082 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=0.0309 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.03093 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.03178 μM | SANGER | |||
| D-336MG | Growth Inhibition Assay | IC50=0.03309 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=0.03354 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.03435 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.0345 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.0348 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.03606 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.03657 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=0.03762 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=0.03807 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=0.03885 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=0.03945 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=0.03985 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.04021 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=0.04103 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.04162 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=0.04203 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=0.04239 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=0.04243 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=0.04272 μM | SANGER | |||
| H9 | Growth Inhibition Assay | IC50=0.04371 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.04447 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.04475 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=0.045 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=0.04549 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=0.04603 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=0.04649 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=0.04753 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=0.04772 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.04789 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=0.04902 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=0.04912 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.04986 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.05 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=0.05039 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=0.05071 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=0.05235 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.05237 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.05296 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.05414 μM | SANGER | |||
| YH-13 | Growth Inhibition Assay | IC50=0.05722 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=0.0574 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=0.05872 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=0.05942 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=0.05964 μM | SANGER | |||
| EPLC-272H | Growth Inhibition Assay | IC50=0.06205 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=0.06237 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.06341 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.06348 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=0.06452 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.06553 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=0.06588 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=0.06591 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=0.06681 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=0.06699 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.06803 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=0.06919 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=0.0695 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=0.07026 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=0.07131 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=0.07208 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=0.07228 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.07255 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.07347 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=0.07589 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=0.07766 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=0.07913 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=0.07969 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=0.07996 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.08043 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.08206 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=0.0821 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=0.08219 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=0.08439 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.08622 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.08728 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=0.09027 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.0906 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=0.09204 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.09262 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=0.09455 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.09472 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.09618 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=0.09677 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.09745 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.09997 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.10054 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=0.10107 μM | SANGER | |||
| A498 | Growth Inhibition Assay | IC50=0.1018 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.10286 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=0.1029 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=0.10307 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=0.10353 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=0.10486 μM | SANGER | |||
| U251 | Growth Inhibition Assay | IC50=0.10525 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=0.10531 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.10554 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.10666 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.10873 μM | SANGER | |||
| TGBC11TKB | Growth Inhibition Assay | IC50=0.10903 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=0.11211 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=0.11264 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=0.11321 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=0.11356 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.11393 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.11764 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=0.11797 μM | SANGER | |||
| BT-549 | Growth Inhibition Assay | IC50=0.11799 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=0.11817 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=0.11982 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.12005 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=0.1202 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=0.12157 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.12157 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=0.12169 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=0.12661 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=0.1269 μM | SANGER | |||
| NCI-H1666 | Growth Inhibition Assay | IC50=0.12774 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=0.12778 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=0.12924 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=0.12943 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=0.1311 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=0.13211 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=0.1341 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=0.13567 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.13762 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.1387 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=0.13883 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.13956 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.14035 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=0.14104 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.14121 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.14125 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=0.14478 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=0.14558 μM | SANGER | |||
| HCC1419 | Growth Inhibition Assay | IC50=0.14576 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=0.14758 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.14839 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=0.14889 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=0.15013 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=0.15225 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.15232 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.15381 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.159 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=0.15966 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=0.16169 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=0.16275 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.16285 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=0.16413 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=0.1654 μM | SANGER | |||
| OC-314 | Growth Inhibition Assay | IC50=0.1669 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=0.16716 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=0.16936 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=0.17173 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=0.17294 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.1733 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.17368 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.17536 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=0.17571 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.17649 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=0.17682 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=0.17734 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=0.17777 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.18082 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=0.182 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=0.18303 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.18394 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.18443 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=0.1845 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=0.18682 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=0.18705 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=0.18872 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=0.19022 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=0.19113 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=0.19116 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=0.19256 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=0.19364 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=0.20057 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=0.20118 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=0.20547 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=0.20564 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.20769 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=0.20848 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.21022 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.21264 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=0.2128 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=0.21298 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=0.21786 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=0.2219 μM | SANGER | |||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.22203 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.22682 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.23084 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.23117 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.23119 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.23681 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=0.23691 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=0.23961 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=0.24044 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=0.24169 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=0.2438 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.24509 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=0.24529 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=0.24563 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.24783 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.24805 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=0.2575 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.25777 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=0.25812 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=0.26136 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.26162 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=0.26363 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.26506 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=0.26599 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.26678 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=0.26742 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=0.27087 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.27265 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=0.27579 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.28074 μM | SANGER | |||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.28956 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=0.29227 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.29277 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.29494 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=0.29872 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=0.30078 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.3054 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.30784 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=0.31251 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=0.31521 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.31715 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=0.31723 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=0.31847 μM | SANGER | |||
| KNS-62 | Growth Inhibition Assay | IC50=0.32088 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=0.32111 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=0.32227 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.32283 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.32753 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.32836 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=0.33159 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=0.33283 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=0.33532 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=0.33619 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=0.33916 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=0.33997 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.34038 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=0.34053 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.34162 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.34501 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.34631 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.35357 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.36829 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=0.3695 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=0.37188 μM | SANGER | |||
| NBsusSR | Growth Inhibition Assay | IC50=0.37285 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=0.37463 μM | SANGER | |||
| CFPAC-1 | Growth Inhibition Assay | IC50=0.37518 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.37862 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=0.3851 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=0.38603 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=0.38703 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=0.38781 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=0.38941 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=0.39699 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=0.40143 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.4117 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.41446 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.41447 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.41682 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=0.41687 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.41981 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.4278 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=0.44183 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=0.4508 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=0.4516 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=0.45437 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.4547 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=0.45569 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=0.46527 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=0.46764 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=0.47446 μM | SANGER | |||
| NCI-H2291 | Growth Inhibition Assay | IC50=0.47896 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=0.48053 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=0.48217 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.49865 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=0.51507 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.52669 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.53177 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=0.53399 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=0.55234 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=0.55762 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=0.56815 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.57977 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=0.58053 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=0.58783 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=0.59124 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.59341 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.60569 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=0.60763 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=0.60969 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=0.61104 μM | SANGER | |||
| UACC-893 | Growth Inhibition Assay | IC50=0.63681 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=0.63804 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.64349 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.65397 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.66323 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=0.66624 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=0.6718 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=0.68679 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=0.68726 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.7 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=0.70829 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.72498 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=0.73671 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.74613 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=0.76467 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=0.77235 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=0.79043 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=0.80004 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.81508 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=0.82231 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=0.85101 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.85141 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=0.85311 μM | SANGER | |||
| NCI-H522 | Growth Inhibition Assay | IC50=0.87783 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=0.87871 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=0.88025 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=0.89356 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=0.90485 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.91185 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=0.91843 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=0.92059 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=0.92591 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.94865 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.95192 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.95424 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.97489 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=0.97634 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=0.98626 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.99982 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=1.00084 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=1.01428 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=1.03121 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=1.05507 μM | SANGER | |||
| SW900 | Growth Inhibition Assay | IC50=1.0783 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=1.07855 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=1.10056 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=1.10154 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=1.10954 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=1.11204 μM | SANGER | |||
| RH-18 | Growth Inhibition Assay | IC50=1.13103 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=1.13333 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=1.13344 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=1.15973 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=1.18306 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=1.19881 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=1.23831 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=1.27394 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=1.30296 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=1.30507 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=1.32407 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=1.35636 μM | SANGER | |||
| NCI-H1838 | Growth Inhibition Assay | IC50=1.36306 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=1.37853 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=1.39094 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=1.39271 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=1.42371 μM | SANGER | |||
| HCT-15 | Growth Inhibition Assay | IC50=1.43068 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=1.45061 μM | SANGER | |||
| ZR-75-30 | Growth Inhibition Assay | IC50=1.47082 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=1.66563 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=1.69607 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=1.72849 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=1.73936 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=1.79759 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=1.82239 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=1.82875 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=1.86988 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=1.89359 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=1.96099 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=2.02337 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=2.03114 μM | SANGER | |||
| SJRH30 | Growth Inhibition Assay | IC50=2.04253 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=2.14111 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=2.15006 μM | SANGER | |||
| NB7 | Growth Inhibition Assay | IC50=2.19673 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=2.20595 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=2.24583 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=2.24782 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=2.25351 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=2.33082 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=2.34408 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=2.39312 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=2.432 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=2.54677 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=2.54947 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=2.63188 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=2.79162 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=2.84692 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=2.85322 μM | SANGER | |||
| EW-22 | Growth Inhibition Assay | IC50=2.92841 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=2.97759 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=3.04376 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=3.05075 μM | SANGER | |||
| NY | Growth Inhibition Assay | IC50=3.08542 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=3.10558 μM | SANGER | |||
| NCI-H2029 | Growth Inhibition Assay | IC50=3.22477 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=3.26027 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=3.3068 μM | SANGER | |||
| CHP-134 | Growth Inhibition Assay | IC50=3.4739 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=3.49168 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=3.50689 μM | SANGER | |||
| CW-2 | Growth Inhibition Assay | IC50=3.55314 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=3.5694 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=3.58414 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=3.62335 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=3.69011 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=3.73029 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=3.91808 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=3.93476 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=4.03518 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=4.0591 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=4.16155 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=4.29999 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=4.32131 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=4.36327 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=4.39736 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=4.45691 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=4.47095 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=4.49657 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=4.54691 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=4.5795 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=4.73814 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=4.75461 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=4.78548 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=4.84545 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=4.85009 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=4.86057 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=4.93184 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=5.12427 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=5.15871 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=5.32339 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=5.36339 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=5.42307 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=5.52201 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=5.72843 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=5.74706 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=5.76627 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=6.09921 μM | SANGER | |||
| D-423MG | Growth Inhibition Assay | IC50=6.40284 μM | SANGER | |||
| ECC10 | Growth Inhibition Assay | IC50=7.10101 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=7.41298 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=7.45523 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=7.45701 μM | SANGER | |||
| NCI-H1993 | Growth Inhibition Assay | IC50=7.83063 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=7.85244 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=7.96049 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=7.99938 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=8.15777 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=8.2032 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=9.36666 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=9.58456 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=9.92352 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=10.8892 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=10.9765 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=11.1472 μM | SANGER | |||
| LU-135 | Growth Inhibition Assay | IC50=11.2307 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=11.3313 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=11.7646 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=11.851 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=12.126 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=12.1541 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=12.5452 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=12.7421 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=12.8215 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=13.671 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=13.7381 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=13.8345 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=14.1602 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=14.3708 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=14.742 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=14.7894 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=15.0425 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=15.0581 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=15.2044 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=15.4414 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=15.5748 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=16.0614 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=16.6214 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=16.8496 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=16.8537 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=17.2028 μM | SANGER | |||
| T84 | Growth Inhibition Assay | IC50=18.8695 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=18.9608 μM | SANGER | |||
| BALL-1 | Growth Inhibition Assay | IC50=19.3399 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=19.492 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=19.598 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=19.7454 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=20.3535 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=20.6505 μM | SANGER | |||
| SW1116 | Growth Inhibition Assay | IC50=20.9362 μM | SANGER | |||
| H-EMC-SS | Growth Inhibition Assay | IC50=22.045 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=22.8261 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=23.2493 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=23.79 μM | SANGER | |||
| JAR | Growth Inhibition Assay | IC50=24.3293 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=24.4753 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=24.8449 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=24.8741 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=25.0928 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=27.1303 μM | SANGER | |||
| MOLT-13 | Growth Inhibition Assay | IC50=27.3516 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=31.3333 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=32.2876 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=33.0055 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=34.0541 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=35.066 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=35.2817 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=37.1536 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=38.4889 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=43.3409 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=43.4768 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=45.1199 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=46.8538 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=48.5058 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=49.6007 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=49.6656 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=49.6976 μM | SANGER | |||
| Click to View More Cell Line Experimental Data | ||||||
Biological Activity
| Description | Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3. | ||
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| Features | Displays very low toxicity toward normal cells. | ||
| Targets |
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| In vitro | ||||
| In vitro | 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3] |
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| Kinase Assay | Hsp90 binding assays | |||
| Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding. | ||||
| Cell Research | Cell lines | BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells | ||
| Concentrations | Dissolved in DMSO, final concentrations ~10 μM | |||
| Incubation Time | 5 days | |||
| Method | Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number. |
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| Experimental Result Images | Methods | Biomarkers | Images | PMID |
| Western blot | α-Synuclein / HSP90 / HSP70 / HSP32 / αB-Crystallin EGFR / PDGFR / AKT / MAPK / c-RAS pAKT / pMAPK / pRb Cleaved PARP / Survivin LATS1 / p-LATS1 / YAP / CTGF |
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20090920 | |
| Immunofluorescence | STAT3 YAP / TAZ β-catenin / E-cadherin |
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27279418 | |
| Growth inhibition assay | Cell viability |
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18682579 | |
| In Vivo | ||
| In vivo | 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2] |
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| Animal Research | Animal Models | Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6 |
| Dosages | ~50 mg/kg | |
| Administration | Injection i.p. | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00103272 | Terminated | Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Waldenström Macroglobulinemia |
National Cancer Institute (NCI) |
April 2005 | Phase 1 |
| NCT00098488 | Terminated | B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia |
National Cancer Institute (NCI) |
April 2005 | Phase 1 |
| NCT00118248 | Completed | Recurrent Thyroid Cancer|Stage IV Follicular Thyroid Cancer|Stage IV Papillary Thyroid Cancer|Thyroid Gland Medullary Carcinoma |
National Cancer Institute (NCI) |
December 2004 | Phase 2 |
| NCT00098423 | Completed | Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Blastic Phase Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts in Transformation|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes |
National Cancer Institute (NCI) |
November 2004 | Phase 1 |
Chemical Information & Solubility
| Molecular Weight | 585.69 | Formula | C31H43N3O8 |
| CAS No. | 75747-14-7 | SDF | Download Tanespimycin (17-AAG) SDF |
| Smiles | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC | ||
| Storage (From the date of receipt) | |||
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In vitro |
DMSO : 100 mg/mL ( (170.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 33 mg/mL Water : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
Question 1:
What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?
Answer:
17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html
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